Partha Pratim Manna

Associate Professor
Ph D (Jadavpur)
Contact Information:

(O)091-542-6701351 ,  Fax: 0542-2368174
Email Id:ppmanna@bhu.ac.in

 
Academic Qualifications:
 
S. No.DegreeInstitutionYear
1.B.Sc.Calcutta University1986
2.M.Sc.Vishva Bharti University1989
3.Ph. D.Indian Institute of Chemical Biology, Kolkata1996
 
 
Brief writeup on area of specialization/awards/achievements:
 

Immunology, Parasitology and Cell Signaling
The primary research goal of our laboratory is to define the biochemical, molecular and functional nature of Dendritic cell in transplant immunology and tumor immunology and evaluate their clinical significance. Studies are also focused on signaling mechanisms involved in CD47 and CD95 mediated cell death in human cancer. We will also investigate the immunopathogenesis of Leishmaniasis to understand the cytokine and chemokine mediated. Cellular and molecular mechanisms using murine models.

Awards:
 

Qualified CSIR NET-JRF , conducted by CSIR-UGC, 1989
Qualified UGC- NET-JRF, conducted by CSIR-UGC, December 1990
Recipient of National Scholarship for School leaving Examination

 
Professional Association:
 

Member, American Society for Cell Biology in 2003.
Life Member, Indian Immunology Society, New Delhi in 2011

 
Current Research Projects:
 
S. No. Name of the Project Duration Source of Funding Amount of Funding (Rs)Any other information
1.Dendritic cell mediated immunotherapy in murine lymphoma: role of cytokine (P.I) 2011-2014 DST
2.Dendritic cell mediated immune response in endothelial cell: implication in transplantation (P.I) 2010-2013 DBT
3.Melatonin and cytokine (IL-2, IL-6, and TNF-α and IFN-γ) cross-talk in regulation of immune function in Indian Goat, Capra hircus (Co.I) 2011-2014 DBT
 
Any additional information:
 Research Associate (2006-2007), Cardiovascular Research Institute, Texas A & M University. Temple, Texas, U.S.A.
Postdoctoral Research Associate (2005-2006), Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, U.S.A.
Postdoctoral Research Associate (2001-2005), Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, U.S.A
Staff Scientist (1999-2001), Department of Immunology, Cancer Research Institute, Tata Memorial Center, Bombay
Research Associate (1997-1999), National Institute of Immunology, New Delhi.

List of recent 10 major publications:

  1. Manna PP, Hira SK, Das AA, Bandyopadhyay S, Gupta KK (2013) IL-15 activated human peripheral blood dendritic cell kill allogeneic and xenogeneic endothelial cells via apoptosis. Cytokine 61: 118-126. S1043-4666(12)00681-3
  2. Manna PP, Chakrabarti G, Bandyopadhyay S.; Innate immune defense in visceral leishmaniasis: cytokine mediated protective role by allogeneic effector cell. Vaccine. 2010 Jan 8; 28(3):803-10.
  3. Hagnerud S*, Manna PP*, Cella M, Stenberg A, Frazier WA, Colonna M, Oldenborg PA. Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration. J Immunol. 2006 May 15; 176(10):5772-8. (* Equal Contribution.)
  4. Manna PP, Dimitry J, Oldenborg PA, Frazier WA. CD47 augments Fas/CD95-mediated apoptosis. J Biol Chem. 2005 Aug 19; 280(33):29637-44.
  5. Manna PP, Frazier WA.CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A. Cancer Res. 2004 Feb 1; 64(3):1026-36.
  6. Manna PP, Jaramillo A, Majumder K, Campbell LG, Fleming TP, Dietz JR, Dipersio JF, Mohanakumar T. Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells. Breast Cancer Res Treat. 2003 May;79(1):133-6.
  7. Manna PP, Frazier WA. The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A. J Immunol. 2003 Apr 1; 170(7):3544-53.
  8. Manna PP, Mohanakumar T. Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro. J Leukoc Biol. 2002 Aug;72(2):312-20.
  9. Manna PP, Duffy B, Olack B, Lowell J, Mohanakumar T. Activation of human dendritic cells by porcine aortic endothelial cells: transactivation of na´ve T cells through costimulation and cytokine generation. Transplantation. 2001 Nov 15; 72(9):1563-71.
  10. Manna PP, Bharadwaj D, Bhattacharya S, Chakrabarti G, Basu D, Mallik KK, Bandyopadhyay S. Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon. Infect Immun. 1993 Aug; 61(8):3565-9.

Full List publications:

  1. Manna PP, Hira SK, Das AA, Bandyopadhyay S, Gupta KK (2013) IL-15 activated human peripheral blood dendritic cell kill allogeneic and xenogeneic endothelial cells via apoptosis. Cytokine 61: 118-126. S1043-4666(12)00681-3
  2. Hira SK, Manna PP.; Down regulation of CD24 and HER-2/neu in breast carcinoma cells by activated human dendritic cell. Role of STAT3. Cell Immunol. 2012 Jan;275(1-2):69-79.
  3. Manna PP, Chakrabarti G, Bandyopadhyay S.; Innate immune defense in visceral leishmaniasis: cytokine mediated protective role by allogeneic effector cell. Vaccine. 2010 Jan 8; 28(3):803-10.
  4. Hagnerud S, Manna PP, Cella M, Stenberg A, Frazier WA, Colonna M, Oldenborg PA. Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration. J Immunol. 2006 May 15; 176(10):5772-8.
  5. Manna PP, Dimitry J, Oldenborg PA, Frazier WA. CD47 augments Fas/CD95-mediated apoptosis. J Biol Chem. 2005 Aug 19; 280(33):29637-44.
  6. Manna PP, Frazier WA.CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A. Cancer Res. 2004 Feb 1; 64(3):1026-36.
  7. Manna PP, Jaramillo A, Majumder K, Campbell LG, Fleming TP, Dietz JR, Dipersio JF, Mohanakumar T. Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells. Breast Cancer Res Treat. 2003 May;79(1):133-6.
  8. Manna PP, Frazier WA. The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A. J Immunol. 2003 Apr 1; 170(7):3544-53.
  9. Jaramillo A, Majumder K, Manna PP, Fleming TP, Doherty G, Dipersio JF, Mohanakumar T. Identification of HLA-A3-restricted CD8+ T cell epitopes derived from mammaglobin-A, a tumor-associated antigen of human breast cancer. Int J Cancer. 2002 Dec 10;102(5):499-506.
  10. Manna PP, Steward N, Lowell J, Mohanakumar T. Differentiation and functional maturation of human CD14(+) adherent peripheral blood monocytes by xenogeneic endothelial cells: up-regulation of costimulation, cytokine generation, and toll-like receptors. Transplantation. 2002 Jul 27;74(2):243-52.
  11. Manna PP, Mohanakumar T. Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro. J Leukoc Biol. 2002 Aug;72(2):312-20.
  12. Adhya S, Hassan MQ, Mukherjee S, Manna PP, Basu A, Sen S, Bandyopadhyay S. Visceral leishmaniasis in India: promises and pitfalls of a PCR-based blood test. Trans R Soc Trop Med Hyg. 2002 Apr;96 Suppl 1:S179-83.
  13. Manna PP, Duffy B, Olack B, Lowell J, Mohanakumar T. Activation of human dendritic cells by porcine aortic endothelial cells: transactivation of na´ve T cells through costimulation and cytokine generation. Transplantation. 2001 Nov 15; 72(9):1563-71.
  14. Metkar SS, Manna PP, Anand M, Naresh KN, Advani SH, Nadkarni JJ. CD40 Ligand--an anti-apoptotic molecule in Hodgkin's disease. Cancer Biother Radiopharm. 2001 Feb;16(1):85-92.
  15. Metkar SS, Naresh KN, Manna PP, Srinivas V, Advani SH, Nadkarni JJ. Circulating levels of TNF alpha and TNF receptor superfamily members in lymphoid neoplasia. Am J Hematol. 2000 Oct;65(2):105-10.
  16. Barbara Olack, Partha Manna, Andres Jaramillo, Nancy Steward, Carol Swanson, Dana Kaesberg, Nancy Poindexter, Todd Howard and T. Mohanakumar (2000). J.Immunol 165, 1294-1299.
  17. Metkar SS, Anand M, Manna PP, Naresh KN, Nadkarni JJ. Ceramide-induced apoptosis in fas-resistant Hodgkin's disease cell lines is caspase independent. Exp Cell Res. 2000 Feb 25;255(1):18-29.
  18. Chakrabarti G, Basu A, Manna PP, Mahato SB, Mandal NB, Bandyopadhyay S. Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis. J Antimicrob Chemother. 1999 Mar;43(3):359-66.
  19. Partha Pratim Manna, Anirban Basu, Asim Saha, Md. Quamarul Hassan, Sandeep Mukherjee, Sabita Majumdar, Samit Adhya and Santu Bandyopadhyay; Leishmania donovani infects lymphocyte cell lines in vitro; Current Science (1997) 73, 610-614.
  20. Chakrabarti G, Basu A, Manna PP, Bhattacharya S, Sen S, Bandyopadhyay S. Peripheral blood mononuclear cells of patients with Indian visceral leishmaniasis suppress natural killer cell activity in vitro. Trans R Soc Trop Med Hyg. 1996 Sep-Oct;90(5):582-5.
  21. Manna PP, Chakrabarti G, Bhattacharya S, Mallik KK, Basu D, Bandyopadhyay S. Plasma of Indian kala-azar patients suppresses natural killer cell activity in vitro. Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):247-8.
  22. Manna PP, Bharadwaj D, Bhattacharya S, Chakrabarti G, Basu D, Mallik KK, Bandyopadhyay S. Impairment of natural killer cell activity in Indian kala-azar: restoration of activity by interleukin 2 but not by alpha or gamma interferon. Infect Immun. 1993 Aug;61(8):3565-9.
  23. Bhattacharya S, Manna PP, Bandyopadhyay S. IFN-gamma is directly cytostatic to the extracellular form (promastigote) of Leishmania donovani. Scand J Immunol. 1993 Jun;37(6):680-3.
© 2018, Banaras Hindu University, [BHU], Varanasi-221005, U.P., India.
Designed and Developed by: Dr. R.S.Yadava, Computer Centre, BHU     |    Redesigned by: Haribansh Mishra ICT Sector, BHU     |    Use a latest browser for best visibility