S K Singh

Professor
Ph.D. (BHU)
Contact Information:

(O) 6702532, (R) 2570668,  Fax:0542-2368174
Email Id:shioks@rediffmail.com

 
Academic Qualifications:
 
S. No.DegreeInstitutionYear
1.B.Sc.Banaras Hindu University1973
2.M.Sc.Banaras Hindu University1975
3.Ph. D.Banaras Hindu University1980
 
Area of specialization/awards/achievements:
 

Reproductive Biology and Endocrinology: Male Reproductive Biology; Fertility Regulation; & Reproductive Toxicology.
Research interests include male reproductive biology, regulation of male fertility and male reproductive toxicology. One of the major aims of his studies has been to explore the plant sources for a safe, effective and reversible contraceptive for use in human. He evaluated the antifertility effects of indigenous plants and, in particular, the effect of Coccinia indica on the reproductive organs and fertility of Parkes (P) male mice. His studies revealed that suppression of spermatogenesis may be caused by germ cell apoptosis resulting from deficiency of testosterone, which, in turn, may result from the adverse effect of Coccinia on steroidogenesis and oxidative status in the testis. A notable feature of his study is that this approach has no effect on libido. His studies have also shown expressions of Orexin A (OXA), a hypothalamic neuropeptide, and its receptor (OX1R) in the testis of neonatal P mice and that the binding of OXA to OX1R is important for the development of the testis. In addition, his studies for the first time revealed that exposure of BDE-209, a common environmental pollutant, to adult male mice caused reduction in serum levels of thyroid hormones and the altered thyroid status partly resulted into impairment of testicular steroidogenesis because of down-regulated expression of SF-1, which, in turn, led to a decrease in germ cell proliferation and thereby suppression of spermatogenesis..

 
Awards & Achievements:
 

  1. Awarded Science Academy Medal for Young Scientists of the Indian National Science Academy (INSA)-1984
  2. Awarded ISCA Young Scientists Award of the Indian Science Congress Association-1984
  3. Awarded Young Academics Award of Malaviya Memorial Foundation of the Banaras Hindu University-1985
  4. Awarded fellowship (direct) of the Japan Society for the Promotion of Science (JSPS) for post doctoral research at the Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan-1987
  5. Awarded postdoctoral fellowship in Reproductive Biology of the Rockefeller Foundation (USA) for research at the Department of Urology, General Hospital and the University, Salzburg, Austria (Europe)1990-1992
  6. A research paper published by us in 2003 in Reproductive Toxicology, 17: 37-44 was appreciated by the scientific committee of the 5th Royan International Research Award in the field of reproductive biomedicine. I was one among the 165 researchers selected from 42 countries whose research papers were invited for consideration of the above award.
  7. Guest edited (by invitation) a Special issue on Male Reproductive Biology of the Indian Journal of Experimental Biology (IJEB)-2005
  8. Edited (by invitation) a book on Endocrinology and Male Reproductive Biology by PHI Learning (formerly Prentice-Hall of India), New Delhi 2013
  9. A faculty from Sudan University of Science & Technology, Khartoum worked in my laboratory (Sept 2013- Feb 2014) for his postdoctoral training under the C V Raman International fellowship programme for African researchers of the Government of India
 
Projects Undertaken as PI/ Co PI:
 
S No. Name of the project Duration Source of funding Amount of funding Any other information
1Localization and expression of orexin A (OXA) and its receptor during postnatal development in mouse testis, and role of OXA in testicular functions.2014-April 2017 ICMR
Any additional information:

 
Editorial Board Member:
(i) Indian Journal of Experimental Biology (a PubMed included periodical), 2011-2014
(ii) World Journal of Biological Chemistry (a PubMed included periodical), 2010-cont.
  • Successfully supervised Ph.D. research work of six students; four are currently working.
  • Reviewer for several journals in area of his research including Journal of Ethnopharmacology, Andrology, Food & Function PLoS ONE; Reproductive Sciences; The European Journal of Contraception & Reproductive Health Care, Systems Biology in Reproductive Medicine, Indian Journal of Experimental Biology, Indian Journal of Biochemistry & Biophysics, Journal of Toxicology and Environmental Health Sciences; Pharmaceutical Biology, Journal of Medicinal Plants Research, Journal of Ayurveda & Integrative Medicine etc.
  • Participated, delivered Invited/Plenary talks, and chaired sessions in several national and international conferences.
  • Reviewer for Research projects - Submitted to Department of Biotechnology (DBT), Indian Council of Medical Research (ICMR) and Council of Scientific & Industrial Research (CSIR), Government of India, New Delhi

    List of 10 major Publications:

    1. Verma, HP and Singh, SK (2016): Antifertility efficacy of Coccinia indica in male mice and its possible mechanisms of action on spermatogenesis. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen.2016.05.007 (in press).
    2. Singh, N and Singh, SK (2016) Citrus limon extract: possible inhibitory mechanisms affecting testicular functions and fertility in male mice. Syst Biol Reprod Med, 62(1): 39-48.
    3. Singh, A. and Singh, SK (2009): Evaluation of antifertility potential of Brahmi in male mouse. Contraception 79:
    4. Singh, A. and Singh, SK (2008): Reversible antifertility effect of aqueous leaf extract of Allamanda cathartca L. in male laboratory mouse. Andrologia, 40: 337-345.
    5. Mishra, R.K. and Singh, SK (2008): Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. Food and Chem Toxicol, 46: 3333-3338.
    6. Patel, SK, Singh S, Singh, HK and Singh, SK (2016): Effect of standardized extract of Bacopa monnieri (CDRI-08) on testicular functions in adult male mice. J Ethnopharmacol, doi.org/10.1016/j.jep.2016.07.026 (in press).
    7. Sarkar, D, Chowdhury, JP and Singh, SK (2015): Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen 2015.11.009 (in press).
    8. Joshi, D and Singh, SK (2015): Localization, expression and role of Orexin A and its receptor in testes of neonatal mice. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen 2015.11.005 (in press).
    9. Singh, SK and Chakravarty, S. (2003): Antispermatogenic and antifertility effects of 20, 25-diazacholesterol dihydrochloride in mice. Reprod. Toxicol, 17: 37-44.
    10. Singh, SK and Chakravarty, S. (2000): Histologic changes in the mouse testis after bilateral vasectomy. Asian J Androl, 2: 115-120.

    11. Full List of Publications:
      A. Referred Scientific Articles in International Journal of repute:

      1. Singh, S.K. and Dominic, C.J. (1978): Sterilization of a nonscrotal mammal (Suncus murinus L.) by intratesticular injection of cadmium chloride. Acta Europ Fertil, 9: 65-70.
      2. Singh, S.K. and Dominic, C.J. (1979): Effect of vasectomy on morphology and motility of epididymal spermatozoa in the musk shrew, Suncus murinus L. Biol Bull India, 1: 17-20.
      3. Singh S.K. and Dominic, C.J. (1979): Effect of DL-6-(N-a-pipecolinomethyl)-5-hydroxyindane maleate (PMHI) on the testis of the musk shrew, Suncus murinus L. Indian J Exp Biol, 17: 724-728.
      4. Singh, S.K. and Dominic, C.J. (1980): Effect of N, N-bis (dichloroacetyl)-1,8-octamethylenediamine (WIN 18446) on the testis and epididymis of the musk shrew, Suncus murinus L. Indian J Exp Biol, 18: 1217-1220.
      5. Singh, S.K. and Dominic, C.J. (1981): Effect of vasectomy on the testis and accessory sex glands of the musk shrew, Suncus murinus L. Endokrinologie, 77: 137-146.
      6. Singh, S.K. and Dominic, C.J. (1981): Effect of vasectomy on the epididymis of a nonscrotal mammal, Suncus murinus L. Indian J Exp Biol, 19: 912-914.
      7. Singh, S.K. and Dominic, C.J. (1981): Failure of 5-thio-D-glucose to induce antispermatogenic effects in the musk shrew, Suncus murinus L. Biol Reprod, 24: 655-659.
      8. Singh, S.K. (1982): Giant cells in the testis of the musk shrew, Suncus murinus L. following vasectomy and treatment with certain antispermatogenic drugs. Science & Culture, 48: 179-180.
      9. Singh, S.K. (1982): Effects of some antifertility chemicals on epididymis of a nonscrotal mammal, Suncus murinus L. Life Sci Adv, 1: 127-131.
      10. Singh, S.K. (1983): Effect of clomiphene citrate on the testis, epididymis and accessory sex glands of the musk shrew, Suncus murinus L. Annls d Endocrinol, 44: 131-138.
      11. Singh, S.K. (1983): Effect of 5-thio-D-glucose on the testis, epididymis and accessory sex glands of the laboratory mouse. Indian J Zoology, 11: 19-25.
      12. Singh, S.K. and Dominic, C.J. (1983): Insensitivity of the testis of the musk shrew to DICA. Arch Androl, 10: 91-92.
      13. Singh, S.K. and Dominic, C.J. (1984): Effect of 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (DICA) on the sex organs of the male laboratory mouse. Exp Clin Endocrinol, 83: 291-296.
      14. Singh, S.K. (1984): Effect of flutamide on the testis and accessory sex glands of the musk shrew, Suncus murinus L. Exp Clin Endocrinol, 84: 20-26.
      15. Singh, S.K. and Dominic, C.J. (1985): Effect of 1-p-chlorobenzyl-1H-indazole-3-carboxylic acid (AF 1312/TS) on the sex organs of the male laboratory mouse. Exp Clin Endocrinol, 84: 297-302.
      16. Singh, S.K. and Dominic, C.J. (1986): Prostaglandin F2a-induced changes in the sex organs of the male laboratory mouse. Exp Clin Endocrinol, 88: 309-315.
      17. Singh, S.K. and Abe, K. (1987): Histologic changes in the mouse testis after efferent duct ligation. Acta Anat Nippon, 62: 676.
      18. Singh, S.K. and Abe, K. (1987): Light and electron microscopic observations of giant cells in the mouse testis after efferent duct ligation. Arch histol jap, 50: 579-585.
      19. Singh, S.K. (1989): Lack of antispermatogenic effect of LHRH antagonist in the musk shrew, Suncus murinus L. Adv Contr Del Syst, 5: 109-116.
      20. Singh, S.K. and Rath, S.K. (1990): Histologic changes in the mouse testis after treatment with gossypol tetra-acetic acid. Arch Histol Cytol, 53: 393-396.
      21. Singh, S.K., Rovan, E. and Frick, J. (1993): Intravasal application of BCG (Bacille Calmette Guerin) is not an effective method for control of fertility in the male: a preliminary report. Contraception, 47: 303-306.
      22. Kerschbaum, H.H., Singh, S.K. and Hermann, A. (1994): Parvalbumin-immunoreactive material in the kidney of Xenopus laevis. Tissue & Cell, 26: 75-81.
      23. Kerschbaum, H.H., Singh, S.K. and Hermann, A. (1995): Lymphoid tissue in the kidney of the musk shrew, Suncus murinus. Tissue & Cell, 27: 421-424.
      24. Rath, S.K. and Singh, S.K. (1996): Effect of DL-6-(N-a-pipecolinomethyl)-5-hydroxyindane maleate (PMHI) on fertility of male mice. J Scientific Res, 46:9-13.
      25. Jungwirth, A.,Weiger, T., Singh, S.K. ,Paulmichl, M. and Frick, J. (1997): Follicle stimulating hormone activates a cAMP-dependent chloride conductance in TM4 Sertoli cells. Biochem Biophys Res Commun, 233: 203-206.
      26. Chakravarty, S. and Singh, S.K. (1998): Effect of 17 a -cyanomethyl-17 b -hydroxy-estra-4,9-dien-3-one on reproductive organs of the male laboratory mouse. Indian J Exp Biol, 36: 1114-1119.
      27. Singh, S.K. and Chakravarty, S. (2000): Histologic changes in the mouse testis after bilateral vasectomy. Asian J Androl, 2: 115-120.
      28. Singh, S.K. and Chakravarty, S. (2001): Effect of nitrofurazone on the reproductive organs in the adult male mouse. Asian J Androl, 3: 39-44.
      29. Mishra, R.K. and Singh, S.K. (2001): Effect of leaf extract of neem (Azadirachta indica) on the reproductive organsof male mouse. J. Androl, 22 (Suppl 1): 116.
      30. Singh, S.K. and Chakravarty, S. (2003): Antispermatogenic and antifertility effects of 20, 25-diazacholesterol dihydrochloride in mice. Reprod. Toxicol, 17: 37-44.
      31. Mishra, R.K. and Singh, S.K. (2005): Effect of aqueous leaf extract of Azadirachta indica on the reproductive organs in male mice. Indian J Exp Biol, Vol. 43: 1093-1103.
      32. Singh, A. and Singh, S.K. (2008): Reversible antifertility effect of aqueous leaf extract of Allamanda cathartica L. in male laboratory mouse. Andrologia, 40: 337-345.
      33. Mishra, R.K. and Singh, S.K. (2008): Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. Food and Chem Toxicol, 46: 3333-3338.
      34. Singh, A. and Singh, S.K. (2009): Evaluation of antifertility potential of Brahmi in male mouse. Contraception 79: 71-79.
      35. Mishra, R.K. and Singh, S.K. (2009): Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception, 79: 479-487.
      36. Mishra, R.K. and Singh, S.K. (2009): Antispermatogenic and antifertility effects of fruits of Piper nigrum L. in mice. Indian J of Exp Biol, 47: 706-714.
      37. Mishra, RK, Verma, HP, Singh, N. and Singh, SK (2012): Male infertility: lifestyle and oriental remedies. Journal of Scientific Research, 56: 93-101.
      38. Mishra, RK and Singh, SK (2013): Reproductive effects of lipid soluble components of Syzygium aromaticum flower bud in male mice. Journal of Ayurveda and Integrative Medicine (in press).
      39. Singh, N and Singh, SK (2016) Citrus limon extract: possible inhibitory mechanisms affecting testicular functions and fertility in male mice. Syst Biol Reprod Med, 62(1): 39-48.
      40. Singh, N and Singh, SK (2016) Aqueous fruit extract of Mimusops elengi causes reversible suppression of spermatogenesis and fertility in male mice. Andrologia, 48: 807-816.
      41. Sarkar, D and Singh, SK (2016): Polybrominated Diphenyl Ethers: Effect on Male Reproductive Health as Thyroid Hormone Disruptors. 18th Edition of the ISSRF Newsletter (ISSN 2395-2806): 19-23.
      42. Patel, SK, Singh S, Singh, HK and Singh, SK (2016): Effect of standardized extract of Bacopa monnieri (CDRI-08) on testicular functions in adult male mice. J Ethnopharmacol, doi.org/10.1016/j.jep.2016.07.026 (in press).
      43. Sarkar, D and Singh, SK (2016): Effect of neonatal hypothyroidism on prepubertal mouse testis in relation to thyroid hormone receptor alpha 1 (THRa1). Gen Comp Endocrinol, doi.org/10.1016/j.ygcen.2016.08.001 (in press).
      44. Mishra, RK and Singh, SK (2016) Biphasic effect of Syzygium aromaticum flower bud on reproductive physiology of male mice. Andrologia, doi: 10.1111/and.12533 (in press).
      45. Verma, HP and Singh, SK (2016): Antifertility efficacy of Coccinia indica in male mice and its possible mechanisms of action on spermatogenesis. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen.2016.05.007 (in press).
      46. Joshi, D and Singh, SK (2016): Localization and expression of Orexin A and its receptor in mouse testis during different stages of postnatal development. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen.2016.05.006 (in press).
      47. Ibrahim, ZH, Joshi, D and Singh, SK (2016): Seasonal immunohistochemical reactivity of S-100 and a-smooth muscle actin proteins in the epididymis of dromedary camel, Camelus dromedaries. Andrologia, doi: 10.1111/and.12667 (in press).
      48. Singh, Neetu, Heneberg, P., Singh, Nidhi, Singh, SK and Rathaur, S (2015): Identification of a novel stress regulated FERM domain containing cytosolic protein having PTP activity in Setaria cervi, a bovine filarial parasite. Biochem Biophys Res Commun, 458: 194-200.
      49. Joshi, D and Singh, SK (2015): Localization, expression and role of Orexin A and its receptor in testes of neonatal mice. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen 2015.11.005 (in press).
      50. Sarkar, D, Chowdhury, JP and Singh, SK (2015): Effect of polybrominated diphenyl ether (BDE-209) on testicular steroidogenesis and spermatogenesis through altered thyroid status in adult mice. Gen Comp Endocrinol, doi.org/10.1016/j.ygcen 2015.11.009 (in press).
      51. Ibrahim, ZH and Singh, SK (2014): Histological and morphometric studies on the dromedary camel epididymis in relation to reproductive activity. Animal Reproduction Science, 149: 212-217.
      52. Verma, HP and Singh, SK (2014): Effect of aqueous leaf extract of Dalbergia sissoo Roxb on spermatogenesis and fertility in male mice. The European Journal of Contraception and Reproductive Health Care, 19(6): 475-486.

        B. Chapters in Book:

        1. Singh, S.K. and Dominic, C.J. (1991): Response of the testis of the musk shrew, Suncus murinus L. to certain antispermatogenic compounds. In: Environmental Contamination and Hygiene (Eds. Ali, A. and Prakash, R.), Environmental Series, Jag Mandar Book Agency, New Delhi, Vol. V, p37-46.
        2. Singh, S.K. (1999): Antispermatogenic agents. In: Comparative Endocrinology and Reproduction (Eds. Joy, K.P., Krishna, A. and Haldar, C.), Narosa/Springer-Verlag, New Delhi, p 285-295.
        3. Singh, S.K. (2006): Testicular toxicity of some chemical agents. In: Advances in Reproductive Toxicology (Eds. Joshi, S.C. and Ansari, A.S.), Pointer International Publishers, Jaipur, p 138-145.
        4. 4. Singh, S.K. and Rath, S.K. (2009): Effect of gossypol tetra-acetic acid on the reproductive organs in male mice. In: Recent Progress in Medicinal Plants (Eds. V.K. Singh and J.N. Govil), Studium Press LLC, Houston, USA, Vol. 25, Chapter 12: 159-176

        C. Book Edited (By invitation):
        1. Singh, SK (2016): Mammalian Endocrinology and Male Reproductive Biology, CRC Press/Taylor & Francis Group, Boca Raton, USA, ISBN-13: 9781498727358.
        2. Singh, S. K. (2013): Endocrinology and Male Reproductive Biology. PHI Learning Private Ltd (formerly Prentice-Hall of India), New Delhi (in press).

        D. Journal Guest Edited (by Invitation):
        1. 1. Singh, S.K. (2005): Special issue on Male Reproductive Biology. Indian Journal of Experimental Biology, Vol. 43, November 2005, pp 935-1109.
        2. 2. Edited, by invitation, a book on Mammalian Endocrinology and Male Reproductive Biology, CRC Press/Taylor & Francis Group, Boca Raton, USA, ISBN 13: 9781498727358, 2016.

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