Dr. Ashim Mukherjee
Professor
Ph.D. (BHU)
Contact Information:
Contact: +91-9919351888 (Cell)
Email Id:amukherjee@bhu.ac.in; ashim04@gmail.com
Academic Qualifications:
 
S. No.DegreeInstitutionYear
1.B.Sc.University of Burdwan,India1985
2.M.Sc.University of Burdwan,India1988
3.Ph.D. Banaras Hindu University,India 1995
 
Professional Employments :

S. No.Name of the Post Name of the DepartmentName of the Inst./UnivDuration
5.ProfessorDepartment of Molecular and Human GeneticsBanaras Hindu University (India)2015-Present
4.Associate ProfessorDepartment of Molecular and Human GeneticsBanaras Hindu University (India)2009-2015
3.ReaderDepartment of Molecular and Human GeneticsBanaras Hindu University (India) 2006-2009
2.Research FellowDepartment of Cell BiologyHarvard Medical School, USA2000-2006
1.Postdoctoral AssociateDepartment of BiologyUniversity of Massachusetts at Amherst, USA1997-2000

 
Area of Specialization:

The major research interest in my laboratory is to understand the mechanism and regulation of Notch signaling. The Notch pathway is an evolutionarily conserved signaling system which has been shown to play major role in cell fate determination, differentiation, proliferation and apoptotic events as well as self-renewal processes of different tissues. The same pathway can be deployed in numerous cellular contexts to play varied and critical roles for the development of an organism. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation. Not surprisingly therefore, aberrant Notch signaling has been implicated in several human pathologies, including carcinogenesis.
In an attempt to identify novel candidates involved in Notch signaling based on their molecular interaction profile using different genomic and proteomic approaches, we have identified many new interactors which may function in different steps of Notch signaling. At present we are working on functional characterization of a few novel interactors identified in our screens. We are particularly interested to gain insights into the role of those novel components which are involved in trafficking and regulation of Notch signals and in cross-talk between Notch and other signaling pathways. We are also working with a few novel components which display synergistic effects with Notch receptor on Notch-induced cell proliferation.

Membership of Scientific Society:
  1. Life Member,Indian Society of Cell Biology

  2. Executive Member, SP RayChowdhury Foundation

  3. Member, Indian Society of Developmental Biologists

  4. Member, International Society for Developmental Biology

  5. Member, The Genetics Society of America

  6. Elected Executive Body Member, Indian Society of Cell Biology

  7. Nominated Member of Drosophila Board, India

Selected Invited Lectures/Resource Person:
  1. 1. Invited talk at Department of Biology, IISER Mohali, Mohali, Punjab, 15 March, 2019.

  2. 2. Invited talk in the International Conference on Advances in Chemical Biology & Biologics, February 28-March 2, 2019 at CSIR-Indian Institute of Chemical Technology, Hyderabad.

  3. 3. Invited talk in the International Conference in Zoology, INTZOOCON 2018, February 1-3, 2018 at Department of Zoology, University of Calcutta.

  4. 4. Invited talk at Department of Biochemistry, University of Delhi South Campus, New Delhi, 15 January, 2015.

  5. 5. Invited talk in International Symposium on Genetic Analysis: Translational and Developmental, November 21-23, 2014, University of Burdwan, West Bengal.

  6. 6. Invited talk at Department of Biochemistry, Indian Institute of Science, Bangalore, 12 September, 2014.

  7. 7. Invited Talk in Drosophila Meeting, March 12, 2014, Banaras Hindu University, Varanasi.

  8. 8. Resource Person in Fourth Refresher Course in Life Sciences, November 17, 2012 UGC-Academic Staff College, University of Burdwan, West Bengal.

  9. 9. Resource Person in a workshop on Basic Techniques in Molecular Biology, January 4-5, 2011 Department of Zoology, Presidency University, Kolkata.

  10. 10. Invited Talk in Golden Jubilee International Seminar, University of Burdwan, West Bengal, March 19, 2010.

  11. 11. Invited Talk in Young Investigators Meeting, Kerala, India, February 24-28, 2009, sponsored by Welcome Trust and DBT.

  12. 12. Invited Talk in Third National Frontiers of Science (NATFOS) Symposium, January 21-22, 2009, sponsored by INSA, Indo-US S&T Forum.

  13. 13. Invited Talk in the Department of Biological Sciences and Bioengineering, IIT, Kanpur, June 20, 2008.

  14. 14. Invited Talk in XXXI All India Cell Biology Conference, December 14-16, 2007, BHU, Varanasi.

Organization of Conferences/Symposium:
  1. 7. Where and How to Publish: Symposium on Ethics in Scientific Publishing, March 27, 2019, BHU Varanasi - Member, Organizing Committee.

  2. 6. Drosophila Meeting, March 12-13, 2014, BHU, Varanasi - Member, Organizing Committee.

  3. 5. 38th Annual Conference of the Indian Society of Human Genetics, December 9-11, 2012, BHU, Varanasi Treasurer.

  4. 4. International Conference on Functional Genomics: Prospects and Challenges. October 2-4, 2010, BHU,Varanasi - Member, Organizing Committee.

  5. 3. International Conference on Emerging Trends in Biotechnology, December 4-6, 2009, BHU, Varanasi - Member, Organizing Committee.

  6. 2. XXXI All India Cell Biology Conference, December 14-16, 2007, BHU, Varanasi -Treasurer.

  7. 1. International Symposium on Environmental Factors, Cellular Stress and Evolution. October 13-15, 2006, BHU, Varanasi - Member, Organizing Committee.

Contribution to the corporate work in Banaras Hindu University:
  1. 6. Served as Head, Department of Molecular and Human Genetics, BHU, April, 2009- March, 2012 (First term), April, 2015-March, 2018 (Second term).

  2. 5. Served as a Chairperson/Convener of different committees such as Departmental PPC, DRC, MSc and PhD Admission Committee, Departmental Board of studies, Departmental Teachers Council etc.

  3. 4. Member of different committees of DBT-BHU-ISLS such as Steering Committee, Equipment Committee, Ad Hoc Board of Studies etc.

  4. 3. Served as a member of University Academic Council.

  5. 2. Member of ISLS group of Functional Genomics, Neuroscience etc.

  6. 1. Adjunct Faculty, Interdisciplinary School of Life Science, BHU

Reviewing Board Member:
  1. Nature Communications, PLoS Genetics, PLoS One, Biomed Central, Journal of Genetics, BBA Journals, Scientific Report etc.

Research Guidance :

  • Doctoral PhD Supervision: 5 (awarded)
  • Post-Graduate M.Sc. Dissertation Supervision: Completed 36 (Since 2006)

    Awards/ Recognitions:

    1. Mentor for Summer Training, Joint Science Academies' Summer Research Fellowship Programme (IASc, INSA & NASI),2010.
    2. Invited in Third Indian National Frontiers of Science Symposium, Sponsored by DST, January 21-22, 2009, New Delhi, India.
    3. Invited in The Young Investigator Meeting, organized by NCBS and DBT-Wellcome Trust, February 24-28, 2009, Kerala, India.
    4. Postdoctoral fellowship, MGH Cancer Center, Harvard Medical School, 2000.
    5. Postdoctoral fellowship, University of Massachusetts, Amherst, 1997.
    6. Visiting fellowship, NCBS, TIFR Centre, Govt. of India, 1995.
    7. National Scholarship, Council for Scientific and Industrial Research, India (for qualifying National Extramural Test), 1993-1994.
    8. National Scholarship, University Grants Commission, India (for qualifying National Extramural Test), 1989-1993.
    9. Qualified Joint CSIR-UGC JRF Examination (National level Extramural Test), 1988.
    10. Qualified GATE 88 (Graduate Aptitude Test in Engineering). Percentile score- 92.08, 1988.
    11. National Merit Scholarship, Govt. of India, 1984-1987.

    List of 10 best publications:

    1. 1. Paul, M.S., Dutta, D., Singh, A., Mutsuddi, M., Mukherjee, A. (2018). Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross. Genesis 56:e23251. doi: 10.1002/dvg.23251. Impact Factor: 2.66
    2. 2. Singh, A., Dutta, D., Paul, M.S., Verma, D., Mutsuddi, M., Mukherjee, A. (2018). Pleiotropic Functions of the Chromodomain-Containing Protein Hat-trick During Oogenesis in Drosophila melanogaster. G3 (Bethesda) 8:1067-1077. Impact Factor: 2.8
    3. 3. Dutta, D., Paul, M.S., Singh, A., Mutsuddi, M., Mukherjee, A. (2017). Regulation of Notch signaling by the heterogeneous nuclear ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster. Genetics116.198879. doi: 10.1534 [Epub ahead of print]. Impact Factor: 5.96
    4. 4. Sachan, N., Mutsuddi, M., Mukherjee, A. (2014). Chip physically interacts with Notch and their stoichiometry is critical for Notch function in wing development and cell proliferation in Drosophila. Biochim Biophys Acta - General Subjects. 1850:802-12. Impact Factor: 5.08
    5. 5. Mishra, A.K., Sachan, N., Mutsuddi, M., Mukherjee, A. (2014). TRAF6 is a novel regulator of Notch signaling in Drosophila melanogaster. Cell Signal 26:3016-3026. Impact Factor: 4.47
    6. 6. Sachan, N., Mishra A.K., Mutsuddi, M., Mukherjee, A. (2013). The Drosophila Importin-a3 is required for nuclear import of Notch in vivo and it displays synergistic effects with Notch receptor on cell proliferation.PLoS One 8:e68247. Impact Factor: 3.73
    7. 7. Mukherjee. A., Veraksa, A., Bauer, A., Rosse, C., Camonis, J., Artavanis-Tsakonas, S. (2005). Regulation of Notch signaling by non-visual ?-arrestin. Nature Cell Biology7:1191-1201. Impact Factor: 19.49
    8. 8. Formstecher, E., Aresta, S., Collura, V., Hamburger, A., Meil, A., Trehin, A., Reverdy, C., Betin, V., Maire, S., Brun, C., Jacq, B., Arpin, M., Bellaiche, Y., Bellusci, S., Benaroch, P.,Bornens, M., Chanet, R., Chavrier, P., Delattre, O., Doye, V., Fehon, R., Faye, G., Galli, T., Girault, J.A., Goud, B., Gunzburg, J.D., Johannes, L., Junier, M.P., Mirouse, V., Mukherjee, A., Papadopoulo, D., Perez, F., Plessis, A., Rosse, C., Saule, S., Stoppa-Lyonnet, D., Vincent, A., White, M., Legrain, P., Wojcik, J., Camonis, J., Daviet, L.(2005). Protein interaction mapping: a Drosophila case study. Genome Research 15:376-384. Impact Factor: 13.69
    9. 9. Moberg, K.H., Mukherjee, A., Veraksa, A., Artavanis-Tsakonas, S., Hariharan, I.K. (2004). The Drosophila F box protein Archipelago regulates dMyc protein levels in vivo. Current Biology 14:965-974. Impact Factor: 10.88
    10. 10. Mukherjee, A., Shan, X., Mutsuddi, M., Ma, Y., Nambu, J.R. (2000). The Drosophila Sox gene, fish-hook, is required for post-embryonic development. Developmental Biology 217:91-106. Impact Factor: 4.407

    A. Full list of Research publications:

    1. 1. Dutta, D., Mutsuddi, M., Mukherjee, A. (2018). Synergistic interaction of Deltex and Hrp48 leads to JNK activation. Cell Biol Int. doi: 10.1002/cbin.11089. Impact Factor: 1.93
    2. 2. Paul, M.S., Dutta, D., Singh, A., Mutsuddi, M., Mukherjee, A. (2018). Regulation of Notch signaling in the developing Drosophila eye by a T-box containing transcription factor, Dorsocross. Genesis 56:e23251. doi: 10.1002/dvg.23251. Impact Factor: 2.66
    3. 3. Dutta, D., Singh, A., Paul, M.S., Sharma, V., Mutsuddi, M., Mukherjee, A. (2018). Deltex interacts with Eiger and consequently influences the cell death in Drosophila melanogaster. Cell Signal 49:17-29. Impact Factor: 4.47
    4. 4. Paul, M.S., Singh, A., Dutta, D., Mutsuddi, M., Mukherjee, A. (2018). Notch signals modulate lgl mediated tumorigenesis by the activation of JNK signaling. BMC Research Reports 11:247. doi: 10.1186/s13104-018-3350-5. Impact Factor: 1.29
    5. 5. Singh, A., Dutta, D., Paul, M.S., Verma, D., Mutsuddi, M., Mukherjee, A. (2018). Pleiotropic Functions of the Chromodomain-Containing Protein Hat-trick During Oogenesis in Drosophila melanogaster. G3 (Bethesda) 8:1067-1077. Impact Factor: 2.8
    6. 6. Gupta, S., Chatterjee, S., Chandra, A., Maurya, O.P.S., Mishra, R.N., Mukherjee, A., Mutsuddi, M. (2018). TP53 codon 72 polymorphism and the risk of glaucoma in a north Indian cohort: A genetic association study. Ophthalmic Genet 39:228-235. Impact Factor: 1.57
    7. 7. Salpietro, V., Efthymiou, S., Manole, A., Maurya, B., Wiethoff, S., Ashokkumar, B., Cutrupi, M.C., Dipasquale, V., Manti, S., Botia, J.A., Ryten, M., Vandrovcova, J., Bello, O.D., Bettencourt, C., Mankad, K., Mukherjee, A., Mutsuddi, M., Houlden, H. (2018). A loss-of-function homozygous mutation in DDX59 implicates a conserved DEAD-box RNA helicase in nervous system development and function. Hum Mutat 39:187-192. Impact Factor: 5.36
    8. 8. Gupta, S., Chatterjee, S., Mukherjee, A., Mutsuddi, M. (2017). Whole exome sequencing: Uncovering causal genetic variants for ocular diseases. Exp Eye Res 164:139-150. Impact Factor: 3.3
    9. 9. Gupta, S., Chaurasia, A., Pathak, E., Mishra, R., Chaudhry, V.N., Chaudhry, P., Mukherjee, A., Mutsuddi, M. (2017). Whole exome sequencing unveils a frameshift mutation in CNGB3 for cone dystrophy: A case report of an Indian family. Medicine (Baltimore) 96:e7490. Impact Factor: 2.2
    10. 10. Tripathi, B.K., Das, R., Mukherjee, A., Mutsuddi, M. (2017). Interaction of Spoonbill with Prospero in Drosophila: Implications in neuroblast development. Genesis 55. 23049. doi: 10.1002. Impact Factor: 2.667
    11. 11. Dutta, D., Paul, M.S., Singh, A., Mutsuddi, M., Mukherjee, A. (2017). Regulation of Notch signaling by the heterogeneous nuclear ribonucleoprotein Hrp48 and Deltex in Drosophila melanogaster. Genetics116.198879. doi: 10.1534 [Epub ahead of print]. Impact Factor: 5.96
    12. 12. Tripathi, B.K., Surabhi, S., Bhaskar, P.K., Mukherjee, A., Mutsuddi, M. (2016). The RNA binding KH domain of Spoonbill depletes pathogenic non-coding spinocerebellar ataxia 8 transcripts and suppresses neurodegeneration in Drosophila. Biochim Biophys Acta Molecular Basis of Diseases 1862:1732-1741. Impact Factor: 5.16
    13. 13. Mishra, A.K., Mukherjee, A. (2016). Recent Advances in Notch Signaling Pathway in Drosophila: A Snapshot. Adv Tech Biol & Med 4:165.
    14. 14. Mishra, A.K., Sachan, N., Mutsuddi, M., Mukherjee, A. (2015). Kinase active Misshapen regulates Notch signaling in Drosophila melanogaster. Exp Cell Res. 15:51-60. Impact Factor: 3.38
    15. 15. Surabhi, S., Tripathi, B.K., Maurya, B., Bhaskar, P.K., Mukherjee, A., Mutsuddi, M. (2015). Regulation of Notch Signaling by an Evolutionary Conserved DEAD Box RNA Helicase, Maheshvara in Drosophila melanogaster. Genetics 201:1071-1085. Impact Factor: 5.96
    16. 16. Gupta, S., Pathak, E., Chaudhry, V.N., Chaudhry, P., Mishra, R., Chandra, A., Mukherjee, A., Mutsuddi, M. (2015). A novel mutation in FRMD7 causes X-linked idiopathic congenital nystagmus in a North Indian family. Neurosci Lett. 597:170-175. Impact Factor: 2.11
    17. 17. Sachan, N., Mutsuddi, M., Mukherjee, A. (2014). Chip physically interacts with Notch and their stoichiometry is critical for Notch function in wing development and cell proliferation in Drosophila. Biochim Biophys Acta - General Subjects. 1850:802-12. Impact Factor: 5.08
    18. 18. Mishra, A.K., Sachan, N., Mutsuddi, M., Mukherjee, A. (2014). TRAF6 is a novel regulator of Notch signaling in Drosophila melanogaster. Cell Signal 26:3016-3026. Impact Factor: 4.47
    19. 19. Gupta, S., Bhaskar, P.K., Bhardwaj, R., Chaudhry, V.N., Chaudhry, P., Ali, A., Mukherjee, A., Mutsuddi, M. (2014). MTHFR C677T predisposes to POAG with greater risk to females, but not to PACG in a North Indian population: a case control study. PLoS One 9:e103063. Impact Factor: 3.73
    20. 20. Bhaskar, P.K., Surabhi, S., Tripathi, B.K., Mukherjee, A., Mutsuddi M. (2014). dLin52iscrucial fordE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid. Biochim Biophys Acta - Gene Regulatory Mechanisms 1839:800-12. Impact Factor: 5.44
    21. 21. Sachan, N., Mishra A.K., Mutsuddi, M., Mukherjee, A. (2013). The Drosophila Importin-a3 is required for nuclear import of Notch in vivo and it displays synergistic effects with Notch receptor on cell proliferation.PLoS One 8:e68247. Impact Factor: 3.73
    22. 22. Bhaskar, P.K., Mukherjee, A., Mutsuddi, M. (2012).Dynamic pattern of expression of dlin52, a member of the Myb/MuvB complex, during Drosophila development. Gene Expression patterns 12:77-84. Impact Factor: 2.037
    23. 23. Mutsuddi, M., Mukherjee, A., Shen, B., Manley, J.L., Nambu, J.R. (2010). Drosophila Pelle phosphorylates Dichaete protein and influences its subcellular distribution in developing oocytes. Int. J. Dev. Biol. 54:1309-1315. Impact Factor: 2.96
    24. 24. Chang, H.C., Dimlich, D.N., Yokokura, T., Mukherjee, A., Kankel, M.W., Sen, A., Sridhar, V., Fulga, T.A., Hart, A.C., Van Vactor, D., Artavanis-Tsakonas, S. (2008). Modeling spinal muscular atrophy in Drosophila. PLoS One 3:e3209. Impact Factor: 3.73
    25. 25. Mukherjee, A., Melnattur, K.V.,Zhang, M., Nambu, J.R. (2006). Maternal expression and function of the Drosophila Sox gene Dichaete during oogenesis. Developmental Dynamics 235:2828-35. Impact Factor: 3.018
    26. 26. Mukherjee. A., Veraksa, A., Bauer, A., Rosse, C., Camonis, J., Artavanis-Tsakonas, S. (2005). Regulation of Notch signaling by non-visual ?-arrestin. Nature Cell Biology7:1191-1201. Impact Factor: 19.49
    27. 27. Formstecher, E., Aresta, S., Collura, V., Hamburger, A., Meil, A., Trehin, A., Reverdy, C., Betin, V., Maire, S., Brun, C., Jacq, B., Arpin, M., Bellaiche, Y., Bellusci, S., Benaroch, P.,Bornens, M., Chanet, R., Chavrier, P., Delattre, O., Doye, V., Fehon, R., Faye, G., Galli, T., Girault, J.A., Goud, B., Gunzburg, J.D., Johannes, L., Junier, M.P., Mirouse, V., Mukherjee, A., Papadopoulo, D., Perez, F., Plessis, A., Rosse, C., Saule, S., Stoppa-Lyonnet, D., Vincent, A., White, M., Legrain, P., Wojcik, J., Camonis, J., Daviet, L.(2005). Protein interaction mapping: a Drosophila case study. Genome Research 15:376-384. Impact Factor: 13.69
    28. 28. Moberg, K.H., Mukherjee, A., Veraksa, A., Artavanis-Tsakonas, S., Hariharan, I.K. (2004). The Drosophila F box protein Archipelago regulates dMyc protein levels in vivo. Current Biology 14:965-974. Impact Factor: 10.88
    29. 29. Mukherjee, A., Shan, X., Mutsuddi, M., Ma, Y., Nambu, J.R. (2000). The Drosophila Sox gene, fish-hook, is required for post-embryonic development. Developmental Biology 217:91-106. Impact Factor: 4.407
    30. 30. Ma, Y., Certel, K., Gao, Y., Niemitz, E., Mosher, J., Mukherjee, A., Mutsuddi, M., Huseinovic, N., Crews, S.T, Johnson, W.A., Nambu, J.R. (2000). Functional interactions between bHLH/PAS, Sox, and POU transcription factors regulate Drosophila CNS midline expression of the slit gene. The Journal of Neuroscience 20:4596-4605. Impact Factor: 7.27
    31. 31. Mukherjee, A.,Roy, J.K. (1996). Molecular genetic analysis of tumour suppressor genes in Drosophila melanogaster. Journal of Scientific Research 46:187-190.
    32. 32. Mukherjee, A.,Roy, J.K. (1995). Altered expression of the wingless segment polarity gene in l(2)gl and l(2)gd tumours. Journal of Biosciences 20:333-339. Impact Factor: 1.65
    33. 33. Mukherjee, A., Lakhotia, S.C., Roy, J.K. (1995). l(2)gl gene regulates late expression of segment polarity genes in Drosophila. Mechanisms of Development 51:227-234. Impact Factor: 2.892
    34. 34. Roy, J.K., Mukherjee, A. (1991). Proto-oncogene homologs in Drosophila. Biology Education 8(3):233-244.

    B. Papers published in Conference Proceedings:

    1. 35. A. Veraksa, A. Mukherjee, A. Bauer and S. Artavanis-Tsakonas (2003) Using TAP technology and proteomics to identify novel modulators of the Notch signaling pathway. The 62nd Annual Meeting of Society for Developmental Biology, Boston. Abstract No. 685. Published in Developmental Biology 259:595 (2003). Impact Factor: 4.407
    2. 36. Ashim Mukherjee and J.R. Nambu (1999) The role of the Drosophila Sox gene, fish-hook, in oogenesis. The 58th Annual Meeting of Society for Developmental Biology, Charlottesville. Abstract No. 218. Published in Developmental Biology 210:217 (1999). Impact Factor: 4.407
    3. 37. M. Mutsuddi, A. Mukherjee and J.R. Nambu (1999) A search for dominant genetic modifiers of the Drosophila fish-hook gene. The 58th Annual Meeting of Society for Developmental Biology, Charlottesville. Abstract No. 354. Published in Developmental Biology 210:239 (1999). Impact Factor: 4.407
    4. 38. Dutta, D., Paul, M.S., Singh, A., Mutsuddi, M., Mukherjee, A. (2016). Deltex and Hrp48 cooperatively downregulate Notch Signaling and induce Apoptosis in Drosophila. Cell Biology Newsletter (ISCB) 35:21-22.
    5. 39. Singh, A., Dutta, D., Paul M.S., Mutsuddi, M., Mukherjee, A. (2017). Pleiotropic functions of CG34422/hat-trick as a maternal gene during oogenesis in Drosophila. Cell Biology Newsletter (ISCB) 36:57-59.

    C. Books and Chapters:

    1. 40. Insights into Human Neurodegeneration: Lessons learnt from Drosophila Editors: Mousumi Mutsuddi and Ashim Mukherjee Book published by Springer-Nature, ebook:ISBN 978-981-13-2218-1, Hard Cover ISBN: 978-981-13-2217-4 (In Press).
    2. Abstracts Published in Conferences (National and International): 62
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